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X-WR-CALNAME:Stewart Blusson Quantum Matter Institute
X-ORIGINAL-URL:https://qmi.miffanytark.com
X-WR-CALDESC:Events for Stewart Blusson Quantum Matter Institute
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SUMMARY:Sabrina Leslie: Single-molecule microscopy of RNA-lipid-nanoparticles: Bringing the nanoscale physics to help advance nanomedicines
DESCRIPTION:Sabrina Leslie: Associate Professor\, UBC Department of Physics and Astronomy and Michael Smith Labs \nAffiliate Faculty member\, SBME\, GSAT\, BIONF \nAbstract: I will present a unique quantitative single-particle imaging platform called CLiC (Convex Lens-induced Confinement) which enables simultaneous measurements of the size\, mRNA-payload\, and dynamic properties of vaccine and other nanoparticles in controlled\, cell-like conditions (Kamanzi et al\, ACS Nano 2021). Recently relocated to UBC PHAS and MSL from McGill in 2021\, our nanoparticle imaging team innovates nanoscale devices and approaches to investigate the structure-activity relationships which can help characterize and understand emerging classes of mRNA-lipid-nanoparticles such as COVID19 vaccines. We image individual confined\, freely diffusing particles in solution as well as during reagent-exchange\, such as in response to a change in solution pH\, in order to emulate/explore intracellular dynamics in a controlled setting. Over the long term and in collaboration with health/therapeutic scientists\, we are working towards correlating detailed multi-scale data sets\, including single-particle measurements made in vitro as well as in cells and tissues\, with clinical results\, to create a through-line of understanding of vaccine/drug effectiveness from the microscopic to clinical scale. Our inspiration is to innovate and use nanoscale tools to obtain new biophysical insights into how and why medicines work to enable and optimize their rational design and engineering. This talk builds off our recent publication in ACS Nano (Kamanzi et al\, 2021)\, describes our ongoing collaboration with the Cullis laboratory and others (UBC Health Sciences)\, and shares an outlook including opportunities for new PHAS and interdisciplinary graduate students at UBC looking to join an exciting interdisciplinary team of biophysicists. The Leslie Lab has recently set up its new laboratory at MSL/NCE with several state-of-the-art microscopes and we are excited to share our work with QMI and get to know our new community through and after this seminar. \n \nCaption: CLiC single-particle imaging and analysis of Lipid Nanoparticles (LNPs) enables characterization of detailed size and loading distributions of RNA–LNP complexes. A) Compressing the flow-cell confines LNPs for extended study. B) Trapped LNPs are shown in microwells. 100s – 1000s of isolated LNPs are imaged in parallel\, a process which can be repeated thousands of times. C) Single-particle tracking is used to obtain LNP trajectories\, which are then used to obtain particle diffusivity/ size (D) as well as intensity/RNA payload (E). This information is then used to define LNP size and RNA payload distributions and inform structure-activity relationships of the nanoparticles in conjunction with other dynamic\, multi-scale and biological data.
URL:https://qmi.miffanytark.com/event/sabrina-leslie-single-molecule-microscopy-of-rna-lipid-nanoparticles-bringing-the-nanoscale-physics-to-help-advance-nanomedicines/
ORGANIZER;CN="Lada Synkova":MAILTO:lada.synkova@ubc.ca
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BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220922T100000
DTEND;TZID=America/Vancouver:20220922T110000
DTSTAMP:20220907T224728Z
CREATED:20220907T224728Z
LAST-MODIFIED:20220907T224728Z
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SUMMARY:Dr. Guosong Hong: Seeing the Sound: Optical and Ultrasonic Brain Interfaces Based on Materials Advances
DESCRIPTION:Dr. Guosong Hong – Stanford University  \nTitle: Seeing the Sound: Optical and Ultrasonic Brain Interfaces Based on Materials Advances \nAbstract: Today’s optical neuromodulation and imaging methods enable causal manipulation of neural activity to dissect complex circuit connections underlying certain behaviors and facilitate brain-computer interfaces. In these approaches\, visible light is commonly used\, thus limiting penetration depth in vivo and necessitating an invasive procedure that damages the endogenous brain tissue and constrains the subject’s free behavior. In this talk\, I will present three recently developed methods to address these challenges based on novel material advances: sono-optogenetics\, infrared optogenetics\, and an intravascular light source. In sono-optogenetics\, we demonstrate that mechanoluminescent materials can convert focused ultrasound into localized light emission for noninvasive optogenetic neuromodulation in live mice. In addition\, inspired by the infrared sensitivity of rattlesnakes\, we developed an approach to use brain-penetrant infrared light for tether-free and implant-free neuromodulation throughout the entire brain in freely behaving mice. Lastly\, we leveraged a biomineral-inspired approach to synthesize nanoscopic phosphors as an intravascular light source. In contrast to conventional external light sources\, this intravascular light source offers deeper tissue penetration for imaging the mouse brain through the uncleared skull. I will conclude my talk by presenting an outlook on how advances in condensed matter may facilitate our understanding of the mind. \nBiography: Dr. Guosong Hong received his Ph.D. in chemistry from Stanford University in 2014 and then carried out postdoctoral studies with at Harvard University. Dr. Hong joined Stanford Materials Science and Engineering and Neurosciences Institute as an assistant professor in September 2018. His research at Stanford aims to develop and apply novel optical and electronic materials for minimally invasive brain interfacing. He is a recipient of the NIH Pathway to Independence (K99/R00) Award\, the MIT Technology Review ‘35 Innovators Under 35’ Award\, the Science PINS Prize for Neuromodulation\, the NSF CAREER Award\, the Walter J. Gores Award for Excellence in Teaching\, and the Rita Allen Foundation Scholars Award.
URL:https://qmi.miffanytark.com/event/dr-guosong-hong-seeing-the-sound-optical-and-ultrasonic-brain-interfaces-based-on-materials-advances/
ORGANIZER;CN="Lada Synkova":MAILTO:lada.synkova@ubc.ca
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BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220929T090000
DTEND;TZID=America/Vancouver:20220929T133000
DTSTAMP:20220920T234912Z
CREATED:20220920T234912Z
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SUMMARY:Synergy Day 2022
DESCRIPTION:AMPEL Synergy Day 2022\nDate: Thursday\, September 29th \nTime: 9:00 am – 2:00 pm. \nLocation: Room 2020 Kaiser Building\, 2332 Main Mall \nRegistration is open to AMPEL and SBQMI members. \nFood will be provided by the Burgurholic food truck (https://burgerholic.ca/food-truck-menu) serving a variety of meat and vegetarian burgers. \nProgram\nOpening \n8:50 – 9:00: Coffee \n9:00 – 9:10: John’s Welcome \nNew Faculty Research Presentations and Synergy Lectures \n9:10 – 9:30: Drew Potter \n9:30 – 10:00: Synergy Lecture\, Lukas Chrostowski \n10:00 – 10:15: Break \n10:15 – 10:35: Ben Britton \n10:35 – 10:45: Safety First \n10:45 – 11:00: Shared Facilities: Nanofab and CFET \n11:00 – 11:20: Sergey Kravchenko \n11:20 – 11:45: Dan Bizzotto  Synergy 2 \n11:45 – 12:05: Joe Salfi Group \n12:10 – 1:30: Lunch (provided) \n1:20 – 2:00: Closing
URL:https://qmi.miffanytark.com/event/synergy-day/
CATEGORIES:UBC event
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DTSTART;TZID=America/Vancouver:20220929T100000
DTEND;TZID=America/Vancouver:20220929T110000
DTSTAMP:20220921T164849Z
CREATED:20220921T164849Z
LAST-MODIFIED:20220921T164849Z
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SUMMARY:CM Seminar: Dr. Tina Rost\, High Entropy Ceramics: Investigating localized structural effects on emerging properties
DESCRIPTION:Speaker: Dr. Tina Rost \nDate: Thursday September 29 2022 \nTime: 10:00 am – 11:00 AM PST \nLocation: Zoom \nZoom Link: https://ubc.zoom.us/j/64243489212?pwd=YkFSMDdxN3Nhbm15aExBdTF6MnBvQT09 \nMeeting ID: 642 4348 9212 \nPasscode: 742838 \n  \nAbstract\nMany properties we observe in materials are a direct consequence of their composition and local structure. High entropy materials are a unique class of systems that do not have a primary composition; rather they contain a near-equimolar distribution of several elements— where no single element serves as host. Such compositional disorder is accompanied by a unique distribution of localized structural distortions that can have a profound effect on properties such as thermal conductivity\, magnetic interaction\, diffusion\, and more. To date\, high entropy metals and ceramics are gaining significant traction in the materials community as unique and interesting properties continue to emerge\, from amorphous-like thermal conductivities to exotic magnetic states. In this talk\, we present and discuss ongoing work on the local characterization of several high entropy compositions exhibiting crystal structures from rocksalts to Kagome lattices. In particular\, the use of X-ray absorption fine structure (XAFS) is demonstrated to aid in understanding such disorder on the local level and how it may influence functional properties \n  \nSpeaker Bio\nDr. Christina Rost is currently an Assistant Professor of Physics at James Madison University in Harrisonburg\, VA. She graduated with a Ph.D. in Materials Science and Engineering from North Carolina State University in 2016\, following both a B.S. and an M.S. in Physics from Indiana University of Pennsylvania. Her Ph.D. focused on the development and phase-characterization of a novel class of oxide systems stabilized through configurational disorder\, named “Entropy Stabilized Oxides”.   After graduation\, Tina was Postdoctoral Research Associate in the Experiments and Simulations in Thermal Engineering (ExSITE) group\, within the Department of Mechanical and Aerospace Engineering at the University of Virginia. There\, her work focused on experimental methods to test thermal properties at extremely high temperatures and thermal transport in complex and high-entropy oxides and carbides. Currently\, her all-undergraduate research group at JMU focuses efforts on complex oxide synthesis and characterization. She is an active member of the American Ceramics Society and the American Physical Society.
URL:https://qmi.miffanytark.com/event/cm-seminar-high-entropy-ceramics-investigating-localized-structural-effects-on-emerging-properties/
CATEGORIES:CM Seminar
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